arboreto
仓库创建 2025年10月20日最近提交 5 小时前SkillHot 收录 20 天前
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能在大规模转录组数据上高效构建调控网络,适合生物信息学分析。
这个 Skill 做什么
从表达数据推断基因调控网络,支持 GRNBoost2/GENIE3 与分布式计算。
从表达矩阵里推断基因调控网络,找出转录因子与靶基因的可能关系,常用 GRNBoost2 或 GENIE3 算法实现。适合对 bulk 或 single-cell RNA-seq 做下游网络分析,把表达变化映射成调控假设时用。特点是基于树的集成回归并支持 Dask 分布式计算,能处理大规模数据集。
▸ 展开 SKILL.md 英文原文
Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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帮我安装这个 skill:https://raw.githubusercontent.com/K-Dense-AI/scientific-agent-skills/main/skills/arboreto/SKILL.md或 curl 直取 SKILL.md
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# Arboreto ## Overview Arboreto is a Python library from [Aerts Lab](https://github.com/aertslab/arboreto) for inferring gene regulatory networks (GRNs) from gene expression data. It parallelizes tree-based ensemble regression (GRNBoost2, GENIE3) with [Dask](https://distributed.dask.org/) across local cores or remote clusters. **Core capability**: Identify which transcription factors (TFs) regulate which target genes based on expression patterns across observations (cells, samples, conditions). **Upstream**: PyPI **0.1.6** (2021-02-09, latest). Docs: [arboreto.readthedocs.io](https://arboreto.readthedocs.io/en/latest/). Primary downstream consumer: [pySCENIC](https://github.com/aertslab/
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